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Neva Press, Inc. 2005

CNS Drug Reviews

Table of Contents

Volume 6, Supplement 1

Session I.  Pharmacologic Approaches to the Enhancement of Cognition
Chairperson:  Alexander Scriabine
1 Introduction
Alexander Scriabine
3 Strategic Issues in the Discovery of Cognitive Enhancers
Gregory M. Rose
4 Drugs that Enhance Learning in Aging Brain
John F. Disterhoft
5 Neurobiologic Basis of Cognitive Decline in Normal Aging and Hypertensive Cardiovascular Disease
Mark B. Moss
7 The Role of Dopamine D1 Receptors in Cognition
Patricia S. Goldman-Rakic
9 D4 Dopamine Receptors and the Molecular Mechanism of Attention
Richard C. Deth
11   Noradrenergic Enhancement of Prefrontal Cortical Cognitive Function
Amy F. T. Arnsten
13   Potential Utility of 5-HT1A Antagonists in the Treatment of Cognitive Loss Associated With Alzheimer's Disease
Lee Schechter
15   Use of Citicoline, a Source of Blood Choline and Cytidine/Uridine, for Neuroprotection
Richard J. Wurtman, C. Watkins, R. K. K. Lee, J. Agut and J. Ortiz
Sesson II.   Pharmacologic Approaches to the Therapy of Alzheimer Disease
Chairperson:  Robert Lee
17 Regulation of Calcium Homeostasis in Brain Aging - A Target for Neuroprotection
Philip W. Landfield and O. Thibault
19 Symptomatic and Disease Modifying Treatments of Alzheimer's Disease
S. Roberts, J. Hendrick, A. Vinitsky, D. Barten, D. Izzarelli, M. Lewis, B. Robertson, R. Wang, J. Corsa, V. Guss, C. Polson, D. Romaniello, P. Chaturvedula, K. Felsenstein and D. Smith
20 Immunophilin Ligands and Anti-inflammatory Drugs Regulate Amyloid Precursor Protein Synthesis and Metabolism
Robert K. K. Lee
22 Hormonal Regulation of Alzheimer's -amyloid Precursor Protein Processing
Huaxi Xu
24 Control of -amyloid Brain Levels by Estrogens
S. Petanceska, K. Duff, E. Frail, V. Nagy, L. Refolo and S. Gandy
26 Neuroimaging in Alzheimer's Disease:  Relevance for the Development of Therapeutic Agents
Christopher H. Van D yck
Session III.   Neurodegeneration and Neuroprotection:  Basic Mechanisms
Chairperson:  Jeffrey D. Kocsis
28 Role of Nicotinic Acetylcholine Receptors in Neurodegeneration or Neuroprotection During Aging
Marina Picciotto
29 Role of Chaperones in Neurodegeneration
Arthur L. Horwich
30 Regulation of Synaptic Stability by Bcl-2 Family Proteins
Leonard K. Kaczmarek and Elizabeth A. Jonas
32 CNS Axon Regeneration and NOGO
Stephen M. Strittmatter
33 Imaging of Dopamine Transporters:  Biomarker for Progression in Parkinson's Disease
Robert B. Innis, John Seibyl and Kenneth Marek
34 Evidence for Neuropathology in Transgenic Mice Overexpressing p25, an Activator of cdk5
Michael K. Ahlijanian
 Session IV.  Pharmacologic Approaches to Neuroprotection
Chairperson:  Leonard K. Kaczmarek
35   The Effects of Olanzapine on Cognition
Alan Breier
36   Neuroprotective Actions of Novel and Potent Agonists of Group II Metabotropic Glutamate Receptors
A. E. Kingston, M. J. O'Neill, A. Bond, W. H. Jordan, J. P. Tizzano, K. I. Griffey, J. A. Johnson, N. Jones, J. A. Monn, D. Lodge and D. D. Schoepp
38   Excitatory Action of mGlu1/5 Receptor Activation in Layer V Pyramidal Cells of the Prefrontal Cortex
G. J. Marek and C. Zhang
39   Discovery of Selective Inhibitors of Neuronal Nitric Oxide Synthase for Neuroprotection
David W. Reif
40   Functional Abnormalities in the Hippocampus and Impaired Hippocampal-dependent Learning in Mice Lacking the 5-HT1A Receptors
Zoltan Sarnyai, Etienne L. Sibille, Constantine Pavlides, Robert J. Fenster, Bruce S. McEwen and Miklos Toth
41   Cell Transplantation Strategies to Repair Damaged Spinal Cord
Jeffrey D. Kocsis
42   Parathyroid-Hormone-Related Protein is a Neuroprotective Endogenous Regulator of L-Type Calcium Channels
O. Chatterjee, I. A. Nakchbandi, W. M. Philbrick, L. K. Kaczmarek, M. L. Brines and A. E. Broadus
43   A Scopolamine-Induced Model of Cognitive Dysfunction in Canines
J. A. Araujo, A. D. Chan and N. W. Milgram
44   Neurotrophic Effects of the Glycosaminoglycan C3 on Dendritic Arborization and Spines in the Adult Rat Hippocampus:  A Quantitative Golgi Study
R. F. Mervis, J. McKean, S. Zats, A. Gum, R. Reinhart, B. Dudas, U. Cornelli, J. M. Lee, S. A. Lorens, J. Fareed and I. Hanin